We are very proud to announce the publication of a major step forward in our understanding of the relationship between disease-related (fibrotic) remodeling of the heart and biomechanics of atrial contraction. Congratulations to first author Dr. Åshild Telle and thank you to our dear friend and collaborator, co-senior author Dr. Christoph Augustin.
This paper is a big deal for our lab for several reasons. First, it include an implementation of fractional factorial design (FFE), a “Design of Experiments” technique Pat spends a lot of time teaching UW BioE undergrads about in BIOEN400! Second, it is published in PLoS Computational Biology, which is a journal we hold in very high regard because of its strenuous emphasis on reproducible and transparent science. To that end, it is published alongside two major repositories, providing unfettered public access to the source code and computational models used in this work. Finally, it is embodies a major milestone in our NIH-funded research project that aims to study “Mechanistic Relationships Between Fibrosis, Fibrillation, and Stroke: Multi-Scale, Multi-Physics Simulations”.
In case it’s not already clear, we are extremely jazzed about this very cool and very nerdy paper!