PI: Patrick Boyle, PhD
Our Lab’s mission is to develop new computational frameworks that can help decipher cardiac arrhythmia mechanisms and explore new frontiers of clinical treatment.
PI: Patrick Boyle, PhD
Photo credit: Joseph K. Yu
Work conducted in the CardSS Lab covers the full “bench to bedside” spectrum between fundamental experiments and integrating simulation findings in clinical workflows. Our projects are highly interdisciplinary and involve frequent and intense interaction with collaborators ranging from cell biologists to cardiac electrophysiologists. Collaborative work is interwoven with our over-arching mission to drive technological innovation relevant to biomedical applications of computational modeling.
The lab’s current major research thrusts include:
Identifying individuals with the fibrotic substrate for AF within a cohort of Embolic Stroke of Unknown Source (ESUS) patients
Combining imaging and intra-procedural mapping data from complex atrial flutter patients to facilitate non-invasive identification of ablation targets
Developing new frameworks for clinically useful but computationally efficient assessment of arrhythmia susceptibility in patient-specific cardiac models
Characterizing robustness of spontaneous hiPSC-CM excitation in image-based computational models via cardiac safety factor (SF) calculations
Quantifying sources of uncertainty in computational simulations of the heart to enable more effective model validation and verification
Our research is supported by the American Heart Association and the National Institutes of Health.
